BPC-157 (Body Protection Compound-157) is a synthetic pentadecapeptide composed of 15 amino acids, derived from a natural protein found in human gastric juice. It is considered one of the most versatile regenerative peptides, with proven cytoprotective properties in multiple organ systems.

Main Benefits:

• Accelerated regeneration of tendons, ligaments and joints

• Rapid healing of muscle and connective tissue injuries

• Repair of the gastrointestinal mucosa (ulcers, IBS, Crohn's disease, colitis)

• Powerful reduction of chronic and acute inflammation

• Promotion of angiogenesis (formation of new blood vessels)

• Increased expression of growth hormone receptors

• Neuronal regeneration and recovery from brain injuries (TBI)

• Protection and repair of organs (liver, pancreas, heart)

• Strengthening the immune system

• Improved intestinal barrier integrity

• Systemic effects - acts throughout the body

Typical Dosages:

Standard Dosage: 250-500 mcg per day (subcutaneous)

- Acute Injuries: 500-1000 mcg per day (divided into 2 doses)

- Gut Health: 200-400 mcg per day (oral or injectable)

Local administration: Inject near the site of the injury (ideal).

Systemic administration: Abdomen or thigh (for general purposes)

Cycle duration: 4-8 weeks, followed by a rest period.

Frequency: Once a day (or split AM/PM for larger doses)

BPC-157 works through multiple mechanisms: it interacts with the nitric oxide system, growth hormone pathways, and fibroblast signaling. It increases the expression of the GH receptor in tendon fibroblasts, enhancing the proliferative effects of growth hormone. It promotes collagen synthesis, activates the FAK-paxillin pathway (essential for tissue regeneration), and modulates inflammatory pathways. It has a short half-life (<30 minutes), is metabolized in the liver, and eliminated by the kidneys.

Unique Advantages:

• Localized AND systemic effect (unlike many peptides)

• Chemical stability resistant to enzymatic degradation

• Non-hormonal - does not affect hormonal axes

• No significant toxicity in preclinical studies

• Applicable to virtually all major types of fabrics

Often Combined With:

• TB-500: Classic stack for soft tissue repair

• Ipamorelin or CJC-1295: For synergy with growth hormone

• L-Glutamine: Additional support for gut health

Clinical Investigation: A 2024 Systematic Review (PMC) analyzed 36 studies (1993-2024) and confirmed that BPC-157 promotes healing by increasing growth factors and reducing inflammation. It improved outcomes in animal models of muscle, tendon, ligament, and bone injuries. A retrospective human study showed that 7 of 12 patients with chronic knee pain reported relief for >6 months after intra-articular injection.

Therapeutic Applications:

• Sports Medicine: Sprains, strains, tendinitis, tears

• Gastroenterology: Leaky gut syndrome, ulcers, inflammatory bowel diseases

• Neurology: Recovery from TBI, nerve damage, neuroprotection

• Orthopedics: Osteoarthritis, cartilage regeneration (especially with hyaluronic acid)

Side Effects: Very rare - possible mild local irritation at the injection site. Preclinical studies have not shown adverse effects on various organ systems.

Important Note: BPC-157 is NOT approved by the FDA for human therapeutic use. The FDA has stated that human safety data is insufficient. It is banned by WADA in competitive sports as an unapproved substance. Unregulated manufacturing may result in impurities. Requires strict medical supervision.