DSIP (Delta Sleep-Inducing Peptide) is a 9-amino acid neuropeptide discovered in 1974 that induces slow-wave (delta) sleep. It is a naturally occurring somnogenic peptide that crosses the blood-brain barrier and regulates multiple endocrine functions and sleep in the central nervous system.

Main Benefits:

• Induction of slow-wave deep sleep (delta sleep)

• Significant improvement in sleep quality and efficiency

• Reduced sleep latency (falling asleep faster)

• Restoration of circadian rhythm and sleep patterns

• Stress modulation and cortisol reduction

• Geroprotective (anti-aging) action

• Reduction of oxidative stress

• Improved blood pressure and cardiac contractility

• Analgesic properties (pain modulation)

• Promising treatment for major depression

• Neuroprotection and post-stroke recovery

• Release of growth hormone

• Opioid detoxification (start: 10 min)

Typical Dosages:

• Typical Dose: 100-300 mcg per dose

• Administration: Subcutaneous injection or slow IV infusion

• Timing: At night before bed

Frequency: As needed or every 3-5 consecutive days.

Mechanism of Action:

Secreted by the hypothalamus, it increases delta waves in the EEG during deep sleep. It acts via NMDA receptors, modulates the HPA axis (stress), preserves mitochondrial function in hypoxia, and reduces free radicals. It co-localizes with ACTH, MSH, and TSH in the pituitary gland and glucagon in the pancreas.

Clinical Evidence:

• Humans: DSIP IV increased sleep by 59% in 130 min. Improved sleep efficiency and latency in chronic insomnia.

• Opioid Case: Successful detoxification, improvement within 10 minutes, no side effects.

• Animals: Mitochondrial preservation, anticonvulsant effects, post-stroke motor recovery

• Anti-Aging: +24.1% lifespan, -22.6% chromosomal aberrations

Combinations:

• DSIP + Melatonin (timing + depth)

• DSIP + Natural Supplements

• DSIP + CBT-I (cognitive behavioral therapy)

Side Effects:

• Generally well tolerated

• Common: Fatigue upon waking, daytime sleepiness, local reactions, headache

• Rare: Mood swings, anxiety

• Naloxone blocks the effects of DSIP

Contraindications:

• Pregnancy/breastfeeding

• Untreated serious psychiatric conditions

• Untreated severe sleep apnea

Legal Status:

• FDA: NOT APPROVED, INVESTIGATION-BASED peptide only

• Human use is EXPERIMENTAL and off-label.

• Long-term data security: LIMITED

Important Note: DSIP is a promising experimental peptide for sleep, stress, and neuroprotection. It differs from sedatives by optimizing the natural sleep rhythm. Contradictory studies on efficacy. NOT approved by the FDA. Use requires strict medical supervision.